By Craig F. Donatucci MD (auth.), Wayne J.G. Hellstrom (eds.)
Androgen Deficiency and Testosterone alternative: present Controversies and Strategies explores the problems round the prognosis and therapy of androgen deficiency. The textual content examines the on hand facts about the analysis and remedy of guys with low testosterone. It additionally examines controversies within the identity and administration of those males. whereas the knowledge contained inside of might be of use to those that specialise in androgen deficiency and sexual drugs, the scope of the booklet will function a resource of easy information regarding testosterone substitute and as a resource of reasoned research of the controversies surrounding testosterone alternative within the getting older male. Physicians and medical professional extenders can be in a position to practice facts administration rules to the evaluate and therapy of fellows with testosterone deficiency; supported by way of the newest perform guidance on hand. The authors symbolize a choose team of physicians with services in androgen deficiency and substitute.
Androgen Deficiency and Testosterone substitute: present Controversies and Strategies might be of serious worth to all physicians and medical professional extenders who convey well-being care to males of every age.
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Extra info for Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies
28. Herzog AG, Levesque LA. Testosterone, free testosterone, nonsex hormone binding globulin, and free androgen index: which testosterone measurement is most relevant to reproduction and sexual function in men with epilepsy? Arch Neurol. 1992;49:133–5. 29. Chen Y, Yazdanpanah M, Wang XY, et al. Direct measurement of serum free testosterone by ultrafiltration followed by liquid chromatography tandem mass spectrometry. Clin Biochem. 2020;43:490–6. 30. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum.
Chapter 3 The Clinical Diagnosis of Androgen Deficiency Gregory C. G. Hellstrom Introduction The clinical diagnosis of androgen deﬁciency can often be a challenge for physicians. 1). The severity of the signs and symptoms between body organs is often discordant, with the magnitude of signs and symptoms often not matching measured testosterone levels. Although the true diagnosis of androgen deﬁciency requires conﬁrmatory laboratory testing of serum testosterone levels , clinicians must often use their best clinical judgment about when to order laboratory tests, since there is insufﬁcient evidence to justify screening for androgen deﬁciency in the general population .
Currently, efforts to create standardization of testosterone assays are underway. Accurate reference ranges for testosterone measurement by liquid chromatographytandem mass spectroscopy are being developed. These norms need to be established in normal healthy patients of varying ages, with normal sexual and reproductive function. Calibration of the methodology and population-based reference ranges for free testosterone by equilibrium dialysis are also needed. Increased accuracy in the measurement of testosterone and SHBG will lead to improvement in calculations of free- and bioavailable testosterone.