Biochemical Regulation of Myocardium by Matti Vornanen (auth.), Roland Vetter, Ernst-Georg Krause

By Matti Vornanen (auth.), Roland Vetter, Ernst-Georg Krause (eds.)

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10, 0-13125 Berlin, Germany 32 from the activity of the coupling protein Gsa but are related to isoform shift of the catalyst of adenylyl cyclase (10, 21]. In addition to alterations in the cardiac cAMP-generation system developmentally controlled expression of cAMP modulated phosphoproteins may also contribute to the diminished ~-adrenergic responsiveness in the pre-/postnatal period of myocardial development. Data from several groups indicated that there are postnatal changes in the Ca 2+ pump system of the sarcoplasmic reticulum, including its regulation by phospholamban [22, 23].

The transblots were reacted with a monoclonal antibody (1 :400 dilution). Troponin I was determined immunologically after protein separation on polyacrylamide gradient gel (5-1S%) 33 Results electrophoresis as described by [29] . For the visualization of the immunoligical signals the ECL-assay was performed. Quantification of the Western blots was performed with the densitometric evaluation by the PDI-Scanner system. Recognition and quantification of inhibitory and stimulatory subspecies of G protein a subunits in the developing rat heart by immunodetection Determination of adenylyl cyclase activity Figure I shows representative immunoblot analyses in which the presence of Gsa was documented in the developing (130 postnatal days) and adult (4 months) rat heart ventricle.

Crease in ~,-adrenergic and M,-muscarinic receptor mRNA levels and unchanged accumulation ofmRNAs coding for G w _' and G", proteins in rat cardiac hypertrophy. J Mol Cell Cardiol 27: 2287-2294, 1995 McDonough AA, Wang J, Farley RA: Significance of sodium pump isofonns in digitalis therapy. J Mol Cell Cardiol27: 1001-1009, 1995 Sweadner KJ, Herrera VLM, Amato S, Moellmann A. Gibbons OK, Repke KRH: Immunologic identification ofNa+,K+-ATPase isofonns in myocardium: Isofonn change in deoxycorticosterone acetate-salt hypertension.

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